Cellular senescence is a phenomenon characterized by the cessation of cell division. In their groundbreaking experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent.  This process is known as “replicative senescence”, or the Hayflick limit. Hayflick’s discovery of mortal cells paved the path for the discovery and understanding of cellular aging molecular pathways. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include both environmental and internal damaging events, abnormal cellular growth, oxidative stress, autophagy factors, among many other things.
The physiological importance for cell senescence has been attributed to prevention of carcinogenesis, and more recently, aging, development, and tissue repair. Senescent cells contribute to the aging phenotype, including frailty syndrome, sarcopenia, and aging-associated diseases. Senescent astrocytes and microglia contribute to neurodegeneration.
Cellular senescence is a natural part of the aging process in which cells no longer function optimally. These cells can accumulate over time, affecting the day to day function of the healthy cells around them.
But there is a hope for us. With high probability the science will discover in the future how to stop the aging process completely. In meantime we should use supplements which seems to be capable to combat effectively the cellular senescence.
They are listed here.
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