What’s the Relationship Between NAD+ & Aging?
Nicotinamide Riboside, NR is a naturally occurring version of vitamin B3 that works as a coenzyme (a substance that enhances the action of an enzyme) to bind with protein molecules and form active enzymes. Specifically, supplementing NR has (among other things) been clinically shown to boost levels of nicotinamide adenine dinucleotide, or NAD+.
This molecule transfers “electrons from one molecule to another, which is how the mitochondria (known as the “powerhouses of cells”) create energy. On top of this, NAD+ may also increase levels of cyclic ADP-ribose, which is a messenger molecule responsible for the exchange of information inside and outside of cells.”
Now, because the communication between cells has been shown to slow with age, it, therefore, stands to reason that supplementing our diet with products like TRU Niagen could potentially help slow cellular aging, and perhaps the aging process as a whole.
The TRU Niagen website refers to a 2016 study published in “Nature” that found—among other things—“human blood NAD+ can rise as much as 2.7-fold with a single oral dose of NR in a pilot study of one individual.”
Each capsule of TRU Niagen contains 125 mg of nicotinamide riboside, a specific form of vitamin B3 that’s said to work at the cellular level to increase NAD+ levels. And although it’s synthesized, the manufacturer emphasizes that this ingredient is nature identical, “meaning that it is identical structurally and functionally to naturally occurring NR.”
Could TRU Niagen Cause Any Side Effects?
The reality is that any dietary supplement has the potential to cause side effects or interact with prescription medications, which is why it’s always a smart idea to talk with your doctor before taking one.
With this said, the TRU Niagen website emphasizes that the NR in Niagen has been classified as GRAS (Generally Recognized as Safe) by the FDA, as a New Dietary Ingredient. The TRU website adds that “safety of intake has been validated in two clinical trials of human subjects consuming up to 1000 mg/day as a single dose and at 1000 mg/day for 6 weeks.”
Take an active role in helping maintain your patient’s health, longer. TRU NIAGEN PRO delivers the highest dose of nicotinamide riboside (NR) per capsule available today. It’s key ingredient is backed by multiple published human trials, and is clinically proven to increase nicotinamide adenine dinucleotide (NAD), the critical catalyst that powers metabolism and helps maintain healthy cellular function.* NAD has been shown to decline with age and metabolic stress . It has also been demonstrated to help support many aspects of healthy aging:* Increases cellular metabolism and energy production. Maintains healthy mitochondria. Promotes cellular repair. Supports muscle function, including maintenance of muscle mass. Maintains healthy cholesterol levels already within the normal range. One capsule per day or as recommended by your healthcare professional.
Compared to many of the other dietary supplements Niagen seems to have some solid clinical support, and comes to us directly from the research team—filled with scientists and other industry leaders—who created it. They also stand behind all of their purchases with a 15-day money back guarantee.
However, since Niagen is a proprietary ingredient, there doesn’t seem to be any meaningful differences between TRU’s version and those from third-party brands.