What is NMN?
NMN or nicotinamide mononucleotide is a naturally occurring compound that stimulates production of another compound, called NAD or nicotinamide adenine dinucleotide. As part of the aging process, your body produces less NAD as you get older.
Sadly, when NAD levels drop with age, inflammation or rusting of the body, shoots up. As studies have shown that keeping inflammation low throughout life is a key factor to living to 110 and beyond, anything you can do to keep inflammation low will help you to enjoy great health at 100. Thus, more NAD and less inflammation could be the way to reverse aging with NMN.
As keeping NAD levels high is important to slow aging and keep inflammation at a minimum, many longevity researchers, including Dr. Shin-ichiro Imai, MD, PhD from the Washington University School of Medicine, tried to see if they could reverse aging with NAD supplements. Sadly, his research, as well as research from other longevity studies, failed.
The Fountain of Youth NMN Mouse Study
Given NAD supplements failed to reverse aging, Dr. Imai and his colleagues approached this challenge from a different angle. Rather than give NAD supplements, what if they gave mice NMN supplements and then let the mice naturally boost NAD by converting NMN to NAD.
This study was wildly successful. Newspapers around the world reported this past week that Dr. Imai may have found the “fountain of youth.” Indeed, this NMN mouse study even landed them a prominent TIME Magazine article.
Dr. Imai and colleagues took adult lab mice and then randomized them to one of three treatment groups. The first group was treated with low-dose NMN dissolved into their drinking water. The second treatment group drank high-dose NMN in their water. Lastly, the third group had nothing added to their water.
Dr. Imai and his team them followed these mice very closely for one year. As lab mice typically live only two years, they followed these mice until old age.
These Washington University researchers found that NMN was absorbed within minutes to the blood stream of mice. Once inside the blood stream, NMN was converted to NAD thereby boosting NAD levels in these mice.
One theoretical concern was that boosting NAD levels could cause tumors to form in these mice. Fortunately, no tumors or any other complications were observed with NMN supplementation.
Interestingly, the observed NMN benefit was only seen in older mice. Dr. Imai theorized that this was because younger mice made enough NAD so their low levels of inflammation weren’t helped by NMN supplementation.
Benefits of NMN
Quite remarkably, this study showed that old mice could be made young, thin, and energetic again with NMN. Indeed, they convincingly showed that you could reverse aging with NMN. Below are the eight key findings of this study.
1. Lower body weight
In this study, mice fed low-dose NMN lost 4% of their body weight. Those fed high-dose NMN lost 9% of their body weight.
2. Increased energy/better mitochondrial function
The mitochondria is the energy power plant of cells. In this study, mice given NMN were much more energetic and had better energy production from their mitochondria.
3. Less diabetes
Mice on NMN showed much better insulin sensitivity. Better insulin sensitivity means less diabetes. Even heavier mice on NMN showed better insulin sensitivity.
4. Lower cholesterol and triglycerides
Researchers found that NMN also dropped cholesterol and triglyceride levels. However, this drop was primarily seen in those mice on high-dose NMN.
5. Less activation of aging genes
As NMN and NAD both activate the SIRT1 longevity gene, these Washington University researchers observed marked activation of longevity genes and suppression of aging genes.
6. Improved eye sight
Researchers found that the retinas in mice functioned much better with NMN supplementation. Also, the older mice were even less likely to suffer from dry eyes.
7. Increased bone density and muscle
Mice treated with NMN also had stronger muscles and bones. Interestingly, the 513 genes that cause loss of muscle and bone density with aging were all suppressed with NMN in this study.
8. Better immune system function
Lastly, NMN treated mice showed better immune function. Better functioning of the immune system means less infections and and less cancer.
Foods Naturally High in NMN
Even though a quick search on Amazon will give you many NMN supplement choices, none of these have been studied. Even if these supplements are “pure,” no one knows what effects they may have to your body. As many studies evaluating supplements in humans often produce unintended side effects or toxicities, it is always best to get everything you need from natural food sources.
Fortunately, NMN is found naturally in many foods. Below are the six foods highest in NMN.
In addition to NMN, eating more of these six foods will help your overall health in so many other ways. However, it should be pointed out that if you want to reverse aging with NMN, you will have to eat large amounts of each of these foods. Sadly, the NMN in a few stems of broccoli is hardly enough to even begin to boost NMN levels.”
broccoli is hardly enough to even begin to boost NMN levels.”
UNSW researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.
Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston and his team identified in an article published in March 2017 edition of Science today a critical step in the molecular process that allows cells to repair damaged DNA.
NMN supplements available today: